The potency of agonists and the affinities of several receptor subtype selective antagonists were determined on smooth muscle strips for the pig internal anal sphincter. Cumulative concentration—response curves were performed using phenylephrine and noradrenaline. Prazosin antagonized responses of the sphincter to phenylephrine and noradrenaline, yielding mean affinity estimates of 8. The Schild slope for prazosin with phenylephrine was equal to unity 1. Faecal incontinence is a common problem that is defined as the uncontrolled passing of faecal material. The treatments for faecal incontinence have varying rates of success but most are associated with unwanted side effects. The internal anal sphincter exhibits spontaneous tonic contraction and a variety of factors influence this resting tone including noradrenaline, acetylcholine, nitric oxide, vasoactive intestinal polypeptide and carbon monoxide Rattan,
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Occurrence: Worldwide. Causes: Mycotoxins; trauma; constipation; dietary problems; tethered on steep slope. Effects: Red lining of rectum protrudes from anus.
The piglet is born with a blind end to its rectum, 5 to 10mm in length with no anus. The incidence in mature herds is usually less than 0. Some piglets may survive to weaning. The condition is heritable but of low penetrance.